Cleopatra IV (Greek : Κλεοπάτρα) was Queen of Egypt briefly from 116-115 BC, jointly with her husband Ptolemy IX Lathyros. She later became queen consort of Syria as the wife of Antiochus IX Cyzicenus.
Cleopatra IV was the daughter of Ptolemy VIII Physcon and Cleopatra III of Egypt. She was born between 138 and 135 BC. She was the sister of Ptolemy IX, Ptolemy X, Cleopatra Selene I and Tryphaena.
Cleopatra IV married her brother Ptolemy IX Lathyros when he was still a prince in ca 119/118 BC. Cleopatra IV may be the mother of Ptolemy XII Auletes and Ptolemy of Cyprus, although an unnamed concubine could be the mother of these two men as well.
In ca 115 BC Cleopatra III forced Cleopatra IV and Ptolemy IX to divorce. She replaced Cleopatra IV with her sister Cleopatra Selene.
Cleopatra IV fled Egypt and went to Cyprus, where she married Antiochus IX Cyzicenus and brought him the army of Antiochus VIII Grypus which she had convinced to follow her. Antiochus IX Cyzicenus (Greek : Αντίοχος ΙΧ Κυζικηνός) was the half brother of the king of Syria, Antiochus VIII Grypus (Greek : Γρύπος). Antiochus VIII Gryphus fought Antiochus IX Cyzicenus and eventually chased him to Antioch. Antiochus VIII Gryphus was married to Cleopatra IV's sister Tryphaena. Tryphaena decided that Cleopatra IV should die and over the protests of her husband summoned some soldiers and had Cleopatra IV murdered in the sanctuary of Daphne in Antioch  In his comprehensive website about Ptolemaic genealogy (www.tyndalehouse.com/Egypt/ptolemies/cleopatra_iv_fr.htm), Christopher Bennett also notes the possibility that Cleopatra IV from her brief marriage to Antiochus IX Cyzicenus may have been the mother of the later Seleucid monarch Antiochus X Eusebes ("the Pious"), who would go on to marry Cleopatra IV's younger sister, Cleopatra Selene (thus making him the spouse of a woman who was both his stepmother (Selene married both of her sisters' widowers, Grypus and Cyzicenus, before marrying Eusebes) and his maternal aunt.)
Cleopatra VI Tryphaena (Greek: Κλεοπάτρα Τρύφαινα) was an Egyptian Ptolemaic queen. She may be identical with Cleopatra V.
There were at least two, perhaps three Ptolemaic women called Cleopatra Tryphaena:
* The daughter of Ptolemy VIII Physcon and Cleopatra III, sister of Ptolemy IX Lathyros, Ptolemy X Alexander I, Cleopatra IV and Cleopatra Selene I . If this Tryphaena also bore the name Cleopatra, has not been attested. This Tryphaena may have been born in early 140 or 141 BC. She married Antiochus VIII Grypus, king of Syria, in 124 BC, and bore him five sons: Seleucus VI Epiphanes, the twin Antiochus XI Epiphanes and Philip I Philadelphus, Demetrius III Eucaerus, and Antiochus XII Dionysus. The couple also had a daughter called Laodice. Tryphaena was killed in Antioch (Greek : Αντιόχεια), capital of Syria, by Antiochus IX Cyzicenus, as a revenge for his own wife's (Cleopatra IV) death by her husband Grypus (in 111 BC).
* Cleopatra V Tryphaena. She was a sister or stepsister and wife of Ptolemy XII Auletes until her mysterious disappearance from the records in 69 BC. If, as some scholars believe, her disappearance is attributable to her death, then it must be assumed that she had a daughter also called Cleopatra Tryphaena.
* This presumed daughter of Cleopatra V and Ptolemy XII Auletes, is called Cleopatra VI Tryphaena by some modern historians and she would have been an older sister of the famous Cleopatra VII. If so, her birth year would correctly be c. 75 BC. Some sources say she died as a child. Others say that when Ptolemy XII fled to Rome to avoid an uprising in Alexandria against him (in 58 BC), she and her sister Berenice IV took control of Ptolemaic Egypt. At the time she and Berenice IV had become very powerful in Egypt, mainly due to the unpopularity of Ptolemy XII after failing to save Cyprus from the Romans. Cleopatra VI Tryphaena is said to have died in 57 BC of unknown reasons, however most historians believe that Cleopatra V did not die in 69 BC and that it was she, together with Berenice IV, who assumed power after the expulsion of Ptolemy XII. In this case a daughter of Ptolemy XII called Cleopatra Tryphaina would be unhistoric. When Ptolemy XII later regained power in 55 BC he had Berenice IV executed.