21. The Colossians are included in this general reconciliation (compare Eph 2:1, 12).
      sometime--"once."
      alienated--from God and salvation: objectively banished from God, through the barrier which God's justice interposed against your sin: subjectively estranged through the alienation of your own wills from God. The former is the prominent thought (compare Ro 5:10), as the second follows, "enemies in your mind." "Actual alienation makes habitual 'enemies'" [BENGEL].
      in your mind--Greek, "in your understanding" or "thought" (Eph 2:3; 4:18).
      by wicked works--rather as Greek, "in your wicked works" (wicked works were the element in which your enmity subsisted).
      yet now--Notwithstanding the former alienation, now that Christ has come, God hath completely reconciled, or restored to His friendship again (so the Greek, compare Note, see on Col 1:20).

JFB.